The lab is currently interested in seven central aims:

1. Understanding the mechanisms of IGF-2 and IGF2R in memory formation and enhancement. Understanding their roles in Angelman syndrome.

2. Identification of the transcriptomes expressed in different brain areas of the hippocampus-dependent memory system, as well as transcriptomic changes with learning and functional roles of transcripts required for memory formation.

3. Identification of the translatome and proteome, and their changes following learning. Understanding the functional roles of proteins required for long-term memory.

4. Identification of the mechanisms that regulate protein metabolism following learning.

5. Characterization of the temporal progression of the biological changes over the consolidation and reconsolidation temporal windows.

6. Identification of the biological mechanisms and neural circuits critical for memory formation during early development.

7. Applying the knowledge of 1-6 to disease models. Currently, we are studying neurodevelopmental disorders.